CONGENITAL DEFICIENCY OF HUMAN R-TYPE BINDING-PROTEINS OF COBALAMIN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (6) , 619-626
Abstract
A family expressing the congenital absence of the R-type binders of cobalamin (Cbl), vitamin B-12, was restudied. The capacity to bind Cbl to R type binders was absent from serum, saliva, cerebrospinal fluid, gastric juice granulocytes, and granulocyte output of the propositus. Serum R did not carry Cbl in vivo. There was no immunological R binder in this saliva, but cross reacting material was detected in his serum. Evidence of a partial expression of the defect was observed in offspring of 2 affected persons. There were no obvious clinical consequences of the defect.