Synthesis and properties of mechanism-based inhibitors and probes for inositol monophosphatase derived from 6-O-(2′-hydroxyethyl)-(1R,2R,4R,6R)-cyclohexane-1,2,4,6-tetraol
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 2353-2356
- https://doi.org/10.1039/c39950002353
Abstract
The 1-phosphate, 2′-phosphate and 1, 2′-cyclic phosphate of 6-O-(2-hydroxyethyl)-cyclohexane-1,2,4,6-tetraol are synthesised and found to be good inhibitors of inositol monophosphatase; the stereochemistry of the most potent inhibitor, the (1R,2R,4R,6R)-1-phosphate, provides useful mechanistic insight into the action of this enzyme, the putative target for lithium therapy.Keywords
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