Studies on the biosynthesis of cholesterol. 9. Formation of phosphorylated derivatives of mevalonic acid in liver-enzyme preparations

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Abstract
The formation of 2 phosphorylated derivatives of mevalonic acid by liver enzymes in the presence of adenosine triphosphate (ATP) and Mg++ is described. The 2 substances were purified by various chromatographic procedures. One of the compounds, MV1, is thought to be 5-phosphomevalonate. The 2d, MV2, contains 2 atoms of P per molecule of mevalonate. Both of these substances are converted into cholesterol more efficiently than is DL-mevalonate, but ATP is still needed in this conversion.