Lidocaine efficacy and toxicity assessed by a new, rapid method
- 31 July 1980
- journal article
- research article
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 28 (2) , 177-181
- https://doi.org/10.1038/clpt.1980.147
Abstract
Lidocaine (L) levels were measured by gas chromatography (GC) and a new technique of direct measurement by enzyme immunoassay (EMIT) in 50 consecutive patients admitted to the Coronary Care Unit who received L. There was no significant difference between the levels by the 2 techniques. There was eradication of most ventricular arrhythmias in 78% of patients, partial effectiveness in 16% and no improvement in 6%. Toxicity was mainly mild CNS effects, noted in 26 of the 50 patients. All 6 patients with serum L > 5.9 .mu.g/ml had signs of toxicity. EMIT was accurate and much faster than the traditional GC method.Keywords
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