THE EFFECTS OF COLESTIPOL HYDROCHLORIDE ON SERUM LIPOPROTEIN LIPID AND APOLIPOPROTEIN B AND A-I CONCENTRATIONS IN CHILDREN HETEROZYGOUS FOR FAMILIAL HYPERCHOLESTEROLEMIA

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Abstract
Colestipol hydrochloride was administered to 28 children with familial hypercholesterolemia type II-A, and its effects on serum lipoproteins were tested against a placebo in a cross-over design. All children consumed a diet low in cholesterol and high in linoleic acid. Colestipol therapy resulted in a 15.7% decrease in serum very low plus low density lipoproteins and in a 13.5% decrease in serum apolipoprotein B. High density lipoprotein cholesterol, serum apolipoprotein A-I and serum triglycerides remained unaltered.