Effect of Ouabain on Acid Secretion and Electrolyte Content of Frog Gastric Mucosa.
- 1 July 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 110 (3) , 613-615
- https://doi.org/10.3181/00379727-110-27595
Abstract
Ouabain in concentrations from 10-3 to 10-6 M inhibits acid secretion by frog gastric mucosas in vitro and at 10-4 M causes tissue Na to rise and K to fall. Increasing K concentration in the medium from 9 to 29 mM largely abolishes the inhibitory effect of 10-4 M ouabain. We conclude that at least some of the inhibitory effect is the result of alteration of intracellular electrolyte pattern.Keywords
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