Mercaptomerin effect on p-aminohippurate transport in man and pentobarbitalized dog

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Abstract
The effects of mercaptomerin on Tmpah in man and the pentobarbital-anesthetized dog were studied by standard clearance methods. Tmpah was depressed to 60% of control values during the 4th to 6th hr of pentobarbital anesthesia. Mercaptomerin administration to the pentobarbitalized dog prevented the depressant effect of pentobarbital on Tmpah from appearing, in that no significant difference in Tmpah was noted between control periods and postmercurial periods in these experiments. Injection of dimercaprol to pentobarbitalized animals receiving mercaptomerin depressed Tmpah to values expected in anesthetized animals which had received no mercaptomerin. Dimercaprol had no effect in anesthetized animals not receiving mercaptomerin. In man, mercaptomerin depressed Tmpah to 50% of control values whether the mercurial was injected before or after commencement of PAH-loading.

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