Melanin Pigmentation and Its Endocrine Control

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Abstract
OBSERVATIONS of the differences in pigmentation in the races of man and in animals may be traced to the writings of Hippocrates, Aristotle, Galen, Rhazes and Pliny. Their works indicated a recognition of the association of pigmented spots with pregnancy and general diseases and the relation between exposure to sunlight and increased pigmentation of the skin. The variations from normal pigmentation were referred to as chloasma and melasma. Deposition of pigment was thought to be due to the mixing of the bile or to an inspissation of the "juices."1 Aristotle, in History of Animals, described the color changes of . . .

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