Biosynthesis of vitamin B12: nature of the volatile fragment generated during formation of the corrin ring system.
- 1 January 1981
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (1) , 11-12
- https://doi.org/10.1073/pnas.78.1.11
Abstract
It is shown with the help of radiolabeled substrates that biological formation of the corrin ligand system of cobyrinic acid is linked with the release of an equivalent of acetic acid from a hydroporphinoid precursor in which the C-20 atom has undergone methylation prior to its excision from the macrocycle.Keywords
This publication has 4 references indexed in Scilit:
- Biosynthesis of vitamin B12: mode of incorporation of factor III into cobyrinic acid.Proceedings of the National Academy of Sciences, 1981
- Ring contraction of hydroporphinoid to corrinoid complexesProceedings of the National Academy of Sciences, 1981
- Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle.Proceedings of the National Academy of Sciences, 1981
- Biosynthesis of porphyrins and related macrocycles. Part 10. Vitamin B12: biochemical derivation of cobyrinic acid from uroporphyrinogen III, studies with the corresponding ring c methyl hepta-carboxylic porphyrinogen, and proof of seven intact methyl transfersJournal of the Chemical Society, Perkin Transactions 1, 1977