Subclasses of Human IgG Molecules Differing in Heterologous Skin Sensitizing Properties

Publisher Website
Google Scholar
Abstract
Summary The γ2a, γ2b, and γ2c-globulin subclasses of human serum IgG were tested for their ability to sensitize heterologous (guinea pig) skin. In studies using 15 G-myeloma proteins, positive RPCA tests were obtained with γ2b and γ2e-myeloma proteins. In contrast, γ2a-myeloma proteins gave negative RPCA reactions. These results indicate that the heavy polypeptide chains of γ2u-globulin molecules differ from the heavy chains of γ2b and γy2c-globulin molecules in skin sensitizing as well as in antigenic properties.