Subclasses of Human γ 2 -Globulin Based on Differences in the Heavy Polypeptide Chains
- 16 October 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 146 (3642) , 400-401
- https://doi.org/10.1126/science.146.3642.400
Abstract
Three subclasses of human γ2-globulin (IgG) molecules were detected in normal human serum with antiserums prepared in monkeys. These subclasses, designated γ2a-, γ2b-, and γ2c-globulins, have antibody activity. The distinguishing antigenic characteristics of each subclass were associated with the heavy polypeptide chains and the F (fast) fragments resulting from treatment of γ2-globulins with papain.Keywords
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