Spatial Resolution Properties of FB and ML-EM Reconstruction Methods

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Abstract
We investigated the spatial resolution and quantitative properties of SPECT images reconstructed using filteredbackprojection (FB) and maximum likelihood-expectation maximization (ML-EM) algorithms. We studied ML-EM as a function of iteration number and projectorhackprojector (php) model, and FE3 as a function of filter. To quantify the image resolution for a shift-variant process we defined a local point response function (PRF). To justify the use of the local PRF to quantify resolution for nonlinear ML-EM we tested the regime over which the algorithm behaved linearly with respect to input perturbations. Using Fourier domain analogs of the local PRF we demonstrated that ML-EM with an accurate php can lead to images of better resolution than FB with a Butterworth or Metz filter or ML-EM with a php that does not fully model the imaging process. We also showed that the resolution improves with increasing MLEM iteration number, and the extent of the improvement depends on the accuracy of the php model. We conclude that the local PRF can be used to characterize spatial resolution in SPECT images, and that ML-EM offers the possibility of superior resolution, particularly if the algorithm contains a good model of the imaging process.