Duodenal ulcer in childhood. A study of predisposing factors.

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Abstract
Follow-up studies were made on 36 children suffering from duodenal ulcer and particular reference was paid to gastric secretory capacity, blood group distribution, family history, and subsequent progress. Males were affected 3 times as often as females. Augmented histamine test meals were performed in 19 children, with results which suggested that acid hypersecretion might be a factor in causation, but the findings were inconclusive. Blood group O was present in excess. A positive family history was present in 1/2 of the patients, and a history of persistent recurrent ulcer symptoms was obtained in almost 3/4. One patient sustained no adverse effects on growth and development following gastric surgery 6 years previously.