THE ROLE OF ASPARTIC ACID IN THE BIOSYNTHESIS OF RICININE1

1 January 1966

journal article
research article
Published by Canadian Science Publishing in Canadian Journal of Chemistry

Vol. 44 (1) , 23-27
https://doi.org/10.1139/v66-004

Abstract

Ricinine, isolated from Ricinuscommunis L. fed aspartic acid-3-¹⁴C and aspartic acid-4-¹⁴C, was degraded, and in each case the activity of all the carbon atoms was determined. The results obtained indicate that aspartic acid is incorporated into ricinine via the Krebs tricarboxylic acid cycle rather than directly as aspartic acid. Experiments with aspartic acid-¹³N support this suggestion; they indicate that the ring nitrogen from ricinine is not derived directly from the nitrogen of aspartic acid, since both it and the nitrile nitrogen contain essentially the same abundance of ¹⁵N.

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