PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - A CASE-REPORT AND REVIEW OF THE LITERATURE
- 1 January 1982
- journal article
- research article
- Vol. 32 (2) , 333-343
Abstract
Progressive multifocal leukoencephalopathy developed in a 70 yr old man with hepatoma treated with oncostatica. The brain showed multiple demyelinated lesions in the upper half of the cerebral white matter. The lesions consisted of prolferation of hypertrophied astrocytes and glial cells with abnormally large nuclei. These nuclei were shown to be filled with DNA by DAPI staining and reacted specifically with anti-JC virus antibody by immunofluorescence. Papova-like virions were confirmed on both the sections and negatively-stained brain extract under EM. The 16 cases so far reported in Japan were reviewed.This publication has 9 references indexed in Scilit:
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