Antibiotics from basidiomycetes. XI. The biological activity of siccayne, isolated from the marine fungus Halocyphina villosa J.&E. Kohlmeyer.

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Abstract
From submerged cultures of the marine basidiomycete H. villosa, siccayne (4-(2,4-dihydroxyphenyl)-2-methyl-1-buten-3-yne) (1) was isolated and is a metabolite first described from fermentations of the deuteromycete Helminthosporium siccans. Siccayne is a moderately active antibiotic, which inhibits gram-positive bacteria and some fungi at concentrations of 10-50 .mu.g/ml. Its cytotoxic effect is much more pronounced on both normal and Rous-sarcoma-virus transformed chicken embryo fibroblasts as compared to cells of the Ehrlich ascites carcinoma. Siccayne apparently interferes with the uptake of nucleoside precursors into eukaryotic cells and with the in vitro incorporation of nucleotides into DNA and RNA.