Tissue-mediated control of immunopathology in coeliac disease
Top Cited Papers
- 1 December 2009
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 9 (12) , 858-870
- https://doi.org/10.1038/nri2670
Abstract
Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation-induced either by infectious agents or by gluten-is crucial for activating T cells and eliciting their tissue-destructive effector functions.Keywords
This publication has 124 references indexed in Scilit:
- Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac DiseaseNew England Journal of Medicine, 2008
- Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3Gastroenterology, 2008
- Gliadin Activates HLA Class I-Restricted CD8+ T Cells in Celiac Disease Intestinal Mucosa and Induces the Enterocyte ApoptosisGastroenterology, 2008
- Newly identified genetic risk variants for celiac disease related to the immune responseNature Genetics, 2008
- Dendritic cells and cytokines in human inflammatory and autoimmune diseasesCytokine & Growth Factor Reviews, 2008
- T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activationNature Immunology, 2008
- A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21Nature Genetics, 2007
- The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine designNature Reviews Immunology, 2006
- Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiationNature Reviews Immunology, 2005
- T cells from the small intestinal Mucosa of a DR4, DQ7/DR4. DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8Human Immunology, 1994