Certain myeloid cells possess receptors for interleukin‐2

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Abstract
Summary. A proportion of blasts from five of 10 cases of AML expressed receptors for IL-2 (IL-2R) when tested directly ex-vivo with monoclonal antibodies against the receptor. After in-vitro stimulation with various agents including TPA, γ interferon and colony stimulating factor, the purified blast cells of all cases of AML tested (10 of 10) showed high levels (50–90% cells positive) of IL-2R expression. Granulocytic cells from the promyelocyte stage onwards lacked IL-2R both before and after in-vitro stimulation. In contrast, leukaemic promonocytes and normal peripheral monocytes expressed IL-2R both before and after stimulation.