Deblocking ofo‐Nitrophenylsulfenyl‐Protected Peptides by Ammonium Thiocyanate and (2‐Methyl‐1‐indolyl)acetic acid
- 16 March 1983
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 66 (2) , 602-605
- https://doi.org/10.1002/hlca.19830660219
Abstract
The thiocyanate cleavage of theNa‐o‐nitrophenylsulfenyl group from peptides in solution or on a solid support proceeds effectively in the presence of (2‐methyl‐1‐indolyl)acetic acid. This scavenger was prepared from 2‐methylindole and sodium bromoacetate; it can readily be removed by extraction with base after the cleavage reaction, together with (2‐methyl‐3‐(2‐nitrophenylthio)‐1‐indolyl)acetic acid.Keywords
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