Reciprocal antimicrobial synergism between Escherichia coli and Bacteroides fragilis in the presence of metronidazole.

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Abstract
The antimicrobial action of metronidazole against B. fragilis and E. coli was studied both in pure cultures and in combination. Concentrations of metronidazole above the minimal inhibitory concentration (MIC) produced a marked bactericidal effect on B. fragilis at 6 h. E. coli showed only a slight and transitory decrease in population when exposed to concentrations of metronidazole close to its MIC. Kinetic studies of this drug''s effect on mixed cultures of both organisms showed mutual bactericidal synergy between E. coli and metronidazole against B. fragilis, and between B. fragilis and metronidazole against E. coli. These in vitro findings agree with the in vivo results of others.

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