NON BUTANOL EXTRACTABLE IODINE IN THE SERUM OF EUMETABOLIC ADULT GOITRE PATIENTS

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Abstract
In studies on endemic goitre there were 20 patients who had more than a normal proportion of butanol insoluble iodine in the serum. All these patients were eumetabolic adults with a goitre ranging in size from 50 to 300 g. The insoluble portion of the PB131I (NBE131I) varied from 25 to 80 per cent, the PB131I from 0.005 to 0.94% per litre. Radiochromatography of the extract revealed that thyroxine made up 30 to 100 per cent, the remainder being iodide. In one case instead of thyroxine, 48 per cent of triiodothyronine was found. In one case traces of diiodotyrosine were found 6 hours after the test dose. Enzymatic hydrolysis increased the extractability in two cases but failed to do so in two other cases. The responses of PBI, PB131I to stimulation with thyrotrophic hormone were studied in some instances. There was usually a good response of PBI and PB131I. The reaction of NBE131I, however, was nil, or very small. The ratio between the values obtained after and before stimulation varied from 1.0 to 1.3. In contrast there was a marked increase in the difference PB131I – NBE131I which presumably represented thyroid hormones. The ratio varied from 2.5 to 3.2. In one case restudied 5 weeks and 3 months after subtotal thyroidectomy the same situation was observed. The occurrence of NBE131I was observed in two members of a family in two instances. In some other families the pedigree was also highly suggestive of an inherited disorder, although it must be admitted that the

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