Genetic Variants of Human Glucose-6-Phosphate Dehydrogenase in a Saharian and Pygmy Family

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Abstract
The distribution of G6PD [G6P dehydrogenase] phenotypes was studied in the inhabitants of a western Sahara oasis and in a group of Bi-Aka pygmies from Central Africa. In both groups there were slow electrophoretic variants with normal or moderately reduced activity. In the Saharians 2 alleles, the Negroid marker GdA- and Gd+Madrona- were found segregating. In the pygmies the Gd+Ibadan-Austin gene was detected. The incidence of these mutations in the groups studied, a comparison with similar G6PD variants observed in other African populations and the geographic distribution of these slow molecules were discussed.