Levels of Ampicillin and Doxycycline in Human Oviduct Mucosa and Serum
- 1 January 1983
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 62 (3) , 231-234
- https://doi.org/10.3109/00016348309155797
Abstract
A common treatment for salpingitis today includes ampicillin (AMPI) and doxycycline (DC), the former against Neisseria gonorrhoeae and the latter against Chlamydia trachomatis. The concentrations of doxycycline in oviduct mucosa were found about equal to that of serum and well above the minimum inhibitory concentrations (MIC) for the bacteria in question. The concentration of AMPI in the oviduct mucosa was only .apprx. 1/40 of that in serum, i.e., 1/10 of the MIC, which jeopardizes the effectivity of AMPI in the treatment of salpingitis.This publication has 6 references indexed in Scilit:
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