Ultrastructure of synovial membrane in osteo-arthritis.

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Abstract
Synovial membranes from 8 cases of osteoarthritis were studied by electron microscopy. Increase in rough endoplasmic reticulum with frequent dilatations of their cisternae was a common abnormality found in synovial cells. There was often an associated reduction in size and number of the Golgi apparatus and of smooth-walled cytoplasmic vesicles. Other abnormalities were increase in lysosomal bodies, alteration in mitochondrial structure, and intracellular edema. Most of these changes were marked in advanced osteoarthritis and hence considered as secondary manifestations of the disease.

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