A Study of the Natural History of Adrenal-Regeneration Hypertension

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Abstract
The natural history of adrenal-regeneration hypertension was studied over a period of 21 weeks. The blood pressure remained elevated in a high percentage of rats with severe adrenal-regeneration hypertensive disease following removal of the regenerated adrenal. Rats with less severe adrenal-regeneration hypertensive disease showed a moderate decline in blood pressure following either removal of the regenerated adrenal or substitution of water for saline drinking solution. A marked fall in blood pressure resulted when the regenerated adrenal was removed and water substituted for saline.