Potency of Vitamin K1 and Two Analogues in Counteracting the Effects of Dicumarol and Sulfaquinoxaline in the Chick

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Abstract
When graded levels of vitamin K1, menadione, or menadione sodium bisulfite complex were added to a vitamin K-deficient diet, 1 mg, 1.15 mg and 1.45 mg respectively, per kilogram of feed were required to obtain prothrombin times indicating an optimum level of plasma prothrombin. When the same compounds were fed with a diet containing 400 mg of dicumarol per kg, the requirement of the chicks appeared to be elevated to 1600 mg of vitamin K1. Up to 8 times this level, on an equimolecular basis, of the two menadione compounds did not counteract the hypoprothrombinemic effect of dicumarol. When the diet contained 0.2% of sulfaquinoxaline, vitamin K1 (4 mg/kg diet), as well as the two forms of menadione, counteracted most but not all of the hypoprothrombinemic effect of this drug.