The Mechanism of Renal Complications in Sulfonamide Therapy

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Abstract
THE ever-increasing number of case reports of renal complications in sulfonamide drug therapy indicates that neither the mechanism of their production nor the means of preventing them is yet understood. The following observations are offered in the hope that they may contribute to a better comprehension of this problem.Early experience with sulfapyridine and sulfathiazole showed that it was mainly the insoluble acetyl derivatives of the drugs that crystallized in the urinary passages, producing obstruction and anuria. It was immediately obvious that a large urinary output would tend to keep these derivatives in solution and to prevent this complication. When . . .