INSULIN ANTIBODIES IN PREGNANT GUINEA PIGS AND IN THEIR OFFSPRING

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Abstract
Insulin antibodies were studied in the maternal and fetal plasma of pregnant guinea pig immunized against insulin. By paper-electrophoresis an insulin binding globulin was found in mother and offspring. Radio-immunoelectropho-retic analysis showed insulin binding antibodies of 3 types in maternal plasma, i. e. in [gamma]1-[gamma]2- and [gamma] M-globulins. Fetal plasma only showed antibody activities in [gamma] 1- and [gamma] 2-globulins. The insulin binding capacity was practically identical in maternal and fetal plasma. Fetuses of passively immunized mothers also showed antibody activity in plasma. The antibody titres of amniotic fluid averaged 1/100 of the plasma titres. The disappearance of the insulin antibodies after birth was followed in 6 offspring. The mean of their half-lifes was 8 days.

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