CHEMICAL CHANGES IN THE RABBIT HEART DURING HYPERTROPHY

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Abstract
When aortic insufficiency is produced in the rabbit heart by rupturing an aortic valve leaflet, rapid changes occur in the chemical composition of the myocardium. During the first 3 days there is a transient increase of the extracellular phase of considerable magnitude. The intracellular phase appears to increase at a more or less constant rate for several wks., after which further increases cannot be clearly distinguished. The hypertrophied hearts at intermediate periods are characterized by a proportion of intracellular phase somewhat greater than normal but of approximately normal composition except for an increased intracellular water content. At later periods a tendency for a loss of intracellular constituents is observed.

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