Influence of phenobarbital and 3-methylcholanthrene on the metabolism of aminopyrine in isolated hepatocyte system.

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Abstract
The effect of phenobarbital (PB) and 3-methylcholanthrene (3-MC) on the metabolic behavior of aminopyrine (AM) was studied using an isolated hepatocyte system prepared from male Wistar rats. The formation of 4-formylaminoantipyrine (FAA) was increased after pretreatment with PB but not 3-MC. The total amounts of AM and its main metabolites recovered from the hepatocyte system after incubation for 30 min were considerably reduced both by PB and 3-MC-pretreatment. When using 4-monomethylaminoantipyrine (MAA), the first metabolite of AM, as a substrate, 3-MC-pretreatment resulted in a more significant decrease in the total amounts of MAA and further metabolites recovered than did PB. The participation of cytochrome P-448 as well as cytochrome P-450 in the metabolism of AM is suggested.

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