Effect of Growth Hormone Upon the Lipids of Bone Matrix

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Abstract
The lipids of the bone matrix of control, hypophysectomized, and hypophysectomized-growth hormone treated (4 mg/rat/day for 7 days) animals were determined. The values found were: control animals: total lipid, 9.34 [plus or minus] 0.38 ([plus or minus]SE); phospholipid, 2.38 [plus or minus]0.15; triglycerides, 0.63 [plus or minus] 0.09; total fatty acid, 5.15[plus or minus]0.21; total cholesterol, 0.62 [plus or minus] 0.02; hypophysectomized animals: total lipid, 21.15[plus or minus]2.62; phospholipids, 3.06 [plus or minus] 0.32; triglycerides, 2.23 [plus or minus] 0.56; total fatty acid, 14.03 [plus or minus] 1.87; total cholesterol, 0.89 [plus or minus] 0.08; hypophysectomized-growth hormone treated animals: total lipid, 10.05 [plus or minus] 0.31; phospholipid, 2.24[plus or minus]0.20; triglycerides, 0.77[plus or minus]0.12; total fatty acid, 5.87 [plus or minus] 0.41; total cholesterol, 0.76 [plus or minus] 0.07. Hypophysectomy significantly increased all the lipids except the phospholipids and treatment with growth hormone restored these values to normal but did not significantly change them from their controls. It appears that the lipids of bone matrix are resistant to lipolysis in a manner similar to that found for other tissues.