Oxidative Metabolism of Normotensive and Hypertensive Rat Tissues

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Abstract
Oxygen uptake studies were made on broken cell prepns. of liver and kidney from normotensive and hypertensive rats. Liver prepns. and prepns. of both kidneys showed no differences. When studied separately the prepns. from the constricted kidney of hypertensive rats exhibited a much lower O2 uptake than its contralateral kidney. Vit. B6 elicited a marked increased in O2 uptake in prepns. from the constricted hypertensive kidney. The oxidation of amino acids and amines was also depressed by prepns. of the constricted kidney; the addition of pyridoxal did not appreciably affect these oxidations.

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