Acute Gouty Arthritis Precipitated by Chlorothiazide

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Abstract
CHLOROTHIAZIDE has recently been shown to be a potent diuretic agent1 for oral use and to have an important antihypertensive effect2 given in conjunction with other hypotensive agents. In addition to its saluretic action, there is a tendency to potassium depletion3 and ammonia retention.4 More recently many authors3 , 5 6 7 8 9 10 have shown that there is a tendency to an elevation of the serum uric acid in patients receiving chlorothiazide in the treatment of hypertension or congestive heart failure and that this was due to a decreased clearance of urate by the renal tubule.5 Serum uric acid levels in the range of 3 . . .