Kinetic studies on the metabolism of foreign organic compounds. 6. Reactions of some nuclear-substituted benzoic acids, benzamides and toluenes in the rabbit

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Abstract
The kinetics of the conjugation of various para substituted benzoic acids with glycine and glucuronic acid, the oxidation of para substituted toluenes and the hydrolysis of para substituted benzamides were investigated in the rabbit. All the processes studied followed first-order reaction kinetics with respect to the administered compound except the glycine conjugation of p-methoxy-, p-iodo-, p-chloro-, p-fluoro- and p-methyl-benzoic acids, administered as such under conditions of glycine inadequacy, when zero-order kinetics were followed. Values for the velocity constants are given. No correlation could be found between the magnitude of the velocity constants and the electronic nature or the size of the substituent groups.