Studies on the Coagulation of Chicken Blood. IX. Labile Factor Activity of Fresh Oxalated Plasma: the Combined Activity of Sixteen Discrete Labile Coagulation Factors.

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Abstract
The labile factor activity of fresh oxalated chicken plasma is fully accounted for by the combined activity of sixteen discrete labile coagulation factors which are active with chicken brain thromboplastin. With Russell''s viper venom (RVV)-cephalin only eight of these factors are active, and the combined activity of the eight factors accounts for all labile factor activity measured by this agent. The labile factor activity measured with RVV, unsupplemented by cephalin, can be accounted for by the combined activity of seven of the eight factors measured by RVV-cephalin. The eight factors specific for the thromboplastin assay system, may be regarded as co-factors for generation of hypothetical intermediate activation products of thromboplastin. The remaining eight factors are probably involved in the transformation of thromboplastin activation products and of RVV-cephalin into prothrombin converting principles. It is suggested that the various labile factors of chicken plasma may be involved in alternative mechanisms for formation of such principles.