The Mechanism of Resistance to Puromycin and to the Puromycin-precursor O-Demethyl-puromycin in Streptomyces alboniger
- 1 November 1985
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 131 (11) , 2877-2883
- https://doi.org/10.1099/00221287-131-11-2877
Abstract
Summary: Ribosomes from Streptomyces alboniger are sensitive in vitro to puromycin and, to a lesser extent, to the puromycin-precursor O-demethyl-puromycin. The puromycin-inactivating enzyme (puromycin N-acetyltransferase) from S. alboniger also N-acetylates Odemethyl-puromycin. This finding indicates that in certain antibiotic-producing organisms the antibiotic-inactivating enzymes may play a role in self-defence against toxic precursor molecules.This publication has 9 references indexed in Scilit:
- Biochemical Basis of Resistance to Hygromycin B in Streptomyces hygroscopicus - the Producing OrganismMicrobiology, 1985
- Cloning and expression of a puromycin N-acetyl transferase gene from Streptomyces alboniger in Streptomyces lividans and Escherichia coliGene, 1985
- Cloning and expression in Streptomyces lividans of a paromomycin phosphotransferase from Streptomyces rimosusforma paromomycinusBiochemical and Biophysical Research Communications, 1984
- Chryscandin, a novel peptidyl nucleoside antibiotic. I Taxonomy, fermentation, isolation and characterization.The Journal of Antibiotics, 1984
- Acetylation of puromycin by Streptomyces, alboniger the producing organismBiochemical and Biophysical Research Communications, 1983
- Biochemical characterization of resistance determinants cloned from antibiotic-producing streptomycetesJournal of Bacteriology, 1982
- Mechanism of resistance to aminoglycoside antibiotics in nebramycin-producing Streptomyces tenebrarius.The Journal of Antibiotics, 1982
- Resistance to the Antibiotics Viomycin and Capreomycin in the Streptomyces Species Which Produce ThemMicrobiology, 1980
- Nucleosides, XXXVI. Synthesis of 3′‐Homocitrullylamino‐ and 3′‐Lysylamino‐3′‐deoxyadenosine and Their Relation to Cordyceps militaris Derived ProductsEuropean Journal of Inorganic Chemistry, 1979