Dynamic Contrast-Enhanced MR Imaging of Bacterial Abscess and VX2 Carcinoma in Rabbits

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Abstract
OBJECTIVE. The objective of this study was to compare enhancement patterns of a blood-pool contrast agent, Gadomer-17, with those of gadopentetate dimeglumine in bacterial abscesses and VX2 carcinoma in rabbits.MATERIALS AND METHODS. Fourteen rabbits with experimentally induced bacterial abscesses and VX2 carcinoma in both thighs underwent dynamic contrast-enhanced MR imaging with Gadomer-17 and gadopentetate dimeglumine at a 24-hr interval. The enhancement ratios (postcontrast to precontrast signal intensities) of lesions in the same animal were assessed and correlated with microvessel density.RESULTS. For Gadomer-17, the enhancement ratio of the abscesses (1.66 ± 0.39) peaked 15 min after the injection, while that of the carcinoma (2.05 ± 0.16) peaked at 10 min. The enhancement ratios of the carcinoma were consistently higher than those of the abscesses up to 30 min. For gadopentetate dimeglumine, peak enhancement ratio of the abscesses (2.30 ± 0.75) was seen 5 min after the injection, while that of the...