Amoxicillin

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Abstract
Amoxicillin was an aminopenicillin available in the USA only for oral use in humans. It has an antibacterial activity and spectrum similar to that of ampicillin and was destroyed by gram-positive and gram-negative .beta.-lactamases. It was more active against enterococci and salmonellae than ampicillin, but less active against Shigella. It is better absorbed than ampicillin from the gastrointestinal tract with blood levels 2-2 1/2 .times. ampicillin. Amoxicillin was an excellent agent to treat otitis media, bacterial sinusitis, bacterial exacerbations of bronchitis, acute lower-urinary-tract infections, gonorrhea and typhoid. In special settings it may be useful as oral therapy of endocarditis, septic arthritis and osteomyelitis and as prophylaxis to prevent endocarditis. When the cost of amoxicillin approaches that of ampicillin, it should replace that agent as the oral aminopenicillin of choice.
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