THE INFLUENCE OF HYPOPHYSECTOMY AND OF GROWTH HORMONE ADMINISTRATION ON THE OXIDATION OF PALMITATE-1-C14BY THE UNANESTHETIZED RAT1

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Abstract
The conversion of intravenously administered albumin-bound palmitate-1-C14 to expired C14O2 by unanesthetized rats was used as an index of fatty acid oxidation. It was found that hypophysectomy did not influence the oxidation of palmitate to CO2 whether this was determined in the fasted or fed state. Bovine growth hormone treatment, chronic or acute, did not appear to enhance the utilization of palmitate by fed or fasted hypophysectomized rats. These findings, along with the evidence of others, suggest that the utilization of fatty acids is under the regulation of factors other than growth hormone.