CARDIOVASCULAR, RENAL, AND GENERAL EFFECTS OF LARGE, RAPID PLASMA INFUSIONS IN CONVALESCENT MEN 1

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Abstract
Ten native Egyptian males, convalescent from infectious diseases were given 900-1955 cc. of reconstituted human plasma in from 5.5-10 min. Increases of blood volume, mean blood pressure, venous pressure, and pulse occurred, while the hematocrit fell. Changes in respiratory rate were inconstant. Especial emphasis was placed on changes in renal function by use of clearance techniques. In 6 cases receiving between 900-1200 cc. of plasma in 5.5-13.5 min., the avg. rise of urine output was 10.9 cc./min., of creatinine clearance was 123 cc./min., and of p-aminohippurate clearance was 703 cc./min. over control levels. The filtered fraction was invariably decreased. In several cases there was an immediate brief drop in one or both clearances prior to the rise. All changes were temporary, tending to return to or toward normal in less than 1 hr. It is concluded that the major responses to large, rapid infusions of plasma are generalized vasodilatation and renal vasodilatation and diuresis.