Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogs as potential antiparasitics
- 1 May 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (5) , 581-584
- https://doi.org/10.1021/jm00179a023
Abstract
A series of 2,4-disubstitued 8-aminoquinoline analogs were synthesized and evaluated against Plasmodium berghei in mice and Leishmania donovani in hamsters. 8-[[6-(Diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against L. donovani. 2-Ethyl-4-methylprimaquine (7a) was evaluated against P. cynomolgi in rhesus monkey and had activity equal to that of primaquine.This publication has 8 references indexed in Scilit:
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