Pathogenesis in Human Obesity

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Abstract
Evidence is presented that impaired satiety rather than increased drive may be responsible for the overeating of some obese persons. Gastric hunger contractions were abolished by the administration of substances which increased the peripheral utilization of glucose. This was true of both non-obese and obese persons. A long-term study of 4 obese women revealed a marked increase in glucose tolerance during periods of life stress characterized by a depressive reaction. Life stress which leads to the overeating of obese persons may result in part from a disordered satiety mechanism mediated by a disturbance of carbohydrate metabolism.