Über das Vorkommen von „sauren Ketosteroiden“ im Harn

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Abstract
In addition to estrone another substance occurs in the alkaline fraction from ethereal urine extracts. This substance, which according to all previous investigations behaves as a typical 17-ketosteroid, must contain in addition a functional acid group which is obviously non-phenolic. In the m-dinitrobenzene reaction the new urine fraction shows a 2nd absorption maximum at 250-260 m[mu] in addition to the normal absorption maximum at 510-520 m[mu] given by all 17-ketosteroids. This substance cannot be an organic acid excreted in the urine or a 3-, 3-, 7-, 11-, 12-, or 20-ketosteroid or acetophenone. These "acid ketosteroids" may be derivatives of cortico-steroids originally containing an aiedhyde group which has been oxidized to a carboxyl group.