Inoculation of Human Malaria into a Simian Host, Macaca mulatta

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Abstract
Monkeys (Macaca mulatta) were inoculated with massive doses of sporozoites of Plasmodium falciparum and P. vivax. No exoerythrocytic parasites were found in a liver biopsy taken after 4 days or in samples of liver, lung, kidney, spleen, and sternal bone marrow taken at necropsy after 6 days from the monkey inoculated with P. falciparum. Similar necropsy of the P. vivax monkey after 6 days also yielded negative results. It appears that a pre-erythrocytic cycle of these parasite strains may not develop in non-splenectomized rhesus monkeys, even after a massive inoculation. One monkey, inoculated with a large number of blood parasites of P. ovale, developed no apparent erythrocytic infection, confirming earlier findings of others.

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