HEPATITIS IN LEPROSY PATIENTS TREATED BY A DAILY COMBINATION OF DAPSONE, RIFAMPIN, AND A THIOAMIDE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 51  (4) , 461-465
Abstract
A 13% incidence of hepatitis was observed among 54 cases of multibacillary leprosy treated daily with the 3-drug combination of dapsone, rifampin and a thioamide (ethionamide or prothionamide). No hepatitis was observed among 109 cases of paucibacillary leprosy treated daily with the 2-drug combination of dapsone and rifampin. Symptoms were jaundice in 5 cases and nausea plus vomiting associated with a significant increase of transaminase levels in 2 cases. In 5 cases, the symptoms appeared during the first 2 mo. of therapy and in 2 cases, later. Discontinuing treatment with rifampin and the thioamide but not dapsone resulted in recovery. When rifampin was resumed without the thioamide, the hepatitis did not recur. Viral etiology could be eliminated in 6 cases. Neither sex, age, weight nor the fact that the patient was a new case or a relapse case appeared to be a contributing factor. Hepatotoxicity caused by administration of a thioamide might have been potentiated by the concurrent administration of rifampin.