CEREBROSPINAL FLUID AND SERUM TRANSAMINASES AND LACTIC DEHYDROGENASE AFTER HEAD INJURY

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Abstract
The GOT [glutamic oxaloacetic transaminase], LDH [lactic dehydrogenase] and GPT [glutamic pyruvic transaminase] activity in cerebrospinal fluid and serum of 30 patients with head injuries was studied within 1-12 hr. of and 72 hr. after the accident. The GOT activity in cerebrospinal fluid had increased significantly in both time intervals in the group of head injury patients as compared with the control group, and the increase was more pronounced in patients with cerebral contusion. Increased LDH activity in cerebrospinal fluid was only seen in patients with cerebral contusion, but not in those with brain concussion. The highest levels were recorded 1 -12 hr. after the trauma, and the difference between these and those of the control group was highly significant. No appreciable changes were noted in the GPT levels of cerebrospinal fluid. In serum, after brain trauma, only GOT activity was clearly higher than in the control group. The increase in GOT was correlated, in the first place, to peripheral contusions, while no definite correlation was observable between the GOT activity in serum and cerebrospinal fluid and the clinical severity of the brain lesion.