A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.
- 1 January 1989
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 42 (8) , 1294-1298
- https://doi.org/10.7164/antibiotics.42.1294
Abstract
C-1027, a new macromolecular antitumor antibiotic produced by Streptomyces globisporus C-1027, showed extremely potent cytotoxicity toward cultured cancer cells. Compared in terms of IC50 values, antibiotic C-1027 showed much more potent cytotoxicity than doxorubicin, mitocmycin C and neocarzinostatin. Spermatogonial assay, a prescreen for anticancer drugs, was highly sensitive for detection of C-1027. At tolerable doses, C-1027 exhibited marked inhibition on a panel of transplantable tumors in mice, which included leukemia L1210, P388, ascites hepatoma H22, sarcoma 180 and melanoma Harding-Passey.This publication has 6 references indexed in Scilit:
- A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties.The Journal of Antibiotics, 1988
- A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.The Journal of Antibiotics, 1988
- Potent antitumor antibiotic complex: PD 114,759, PD 115,028, PD 119,707, and PD 119,193.The Journal of Antibiotics, 1985
- New antitumor antibiotics, FR-900405 and FR-900406. II. Production, isolation, characterization and antitumor activity.The Journal of Antibiotics, 1985
- The fermentation, isolation and characterization of macromolecular peptide antibiotics: AN-7A, -7B and -7D.The Journal of Antibiotics, 1984
- CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism.The Journal of Antibiotics, 1978