THE EFFECT OF METIAMIDE ON ACID SECRETION STIMULATED BY GASTRIN, ACETYLCHOLINE AND DIBUTYRYL CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE IN THE ISOLATED WHOLE STOMACH OF THE RAT

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Abstract
1 An isolated stomach preparation from immature rats is described. The lumen of the stomach was perfused and the hydrogen ion activity of the perfusate recorded continuously. 2 The preparation gave dose-dependent responses to gastrin, acetylcholine and dibutyryl cyclic adenosine 3′,5′-monophosphate and these responses were readily reversed on washing out the agonist. 3 The acid secretory response to gastrin was inhibited by metiamide at concentrations of 10−5 M and 3 × 10−5 m. 4 The acid secretory responses to acetylcholine and dibutyryl cyclic adenosine 3′,5′-monophosphate were not inhibited by concentrations of metiamide up to 10−3 m. 5 These findings are discussed in relation to the role of histamine in the control of gastric acid secretion.