An Analysis of Some Components of Variation in Clinical Chemistry

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Abstract
Using 2 daily unknown serum samples from 5 frozen serum pools, within-day (duplicate) and day-to-day variability were measured by standard deviations and coefficients of variation for the glucose and urea nitrogen determinations. Variability in terms of % T and mg. per 100 ml. was measured for the individual technicians and for the technical staff as a group. The study demonstrated that, even for individual technicians, the within-day variability is considerably less than the day-to-day variability. The study also demonstrates that the act of dilution is not the chief cause of variability in serum that requires diluting prior to testing.

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