Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes
- 1 August 1991
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 277 (3) , 899-902
- https://doi.org/10.1042/bj2770899
Abstract
Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.Keywords
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